Genistein-4,6,2',3',5',6'-d6
| Product Name |
Genistein-4,6,2',3',5',6'-d6
|
| Product Code |
DA-G070-a
|
| Chemical name |
Genistein-4,6,2',3',5',6'-d6
|
| Synonyms |
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d6; Baichanin A-d6; Bonistein-d6; 4',5,7-Trihydroxyisoflavone-d6; GeniVida-d6; Genisteol-d6; Prunetol-d6; Sophoricol-d6;
|
| Impurity |
NA
|
| CAS Number |
197657-74-2
|
| Alternate CAS # |
NA
|
| Molecular form |
C15H4D6O5
|
| Appearance |
Light Yellow Solid
|
| Melting Point |
NA
|
| Mol. Weight |
276.27
|
| Storage |
2-8°C Refrigerator
|
| Solubility |
NA
|
| Stability |
NA
|
| Category |
enzyme inhibitors,stable isotopes,tyrosine kinase inhibitors
|
| Boiling Point |
NA
|
| Applications |
Labelled Genistein. Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.
|
| Dangerous Goods Info |
NA
|
| References |
NA
|
| Extra Notes |
NA
|
| Documents (MSDS) |
No Data Available
|
| Keywords |
NA |
