Product

AMG-458

Product Name AMG-458
Product Code A00009400
Chemical name AMG-458
Synonyms 1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; 2,3-Dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide;
Impurity
CAS Number 913376-83-7
Alternate CAS #
Molecular form C₃₀H₂₉N₅O₅
Appearance
Melting Point
Mol. Weight 539.58
Storage
Solubility
Stability
Category
Boiling Point
Applications AMG-458 is a potent inhibitor of c-Met with an IC50 of 60 nM.
Dangerous Goods Info
References Liu, Longbin., et al.: J. Med. Chem., 51, 3688 (2008);
Extra Notes
Documents (MSDS) No Data Available
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Product Packings
1mg
5mg
10mg