Product

AMG 837 Hemicalcium Salt

Product Name AMG 837 Hemicalcium Salt
Product Code A00009403
Chemical name AMG 837 Hemicalcium Salt
Synonyms (βS)-β-1-Propyn-1-yl-4-[[4’-(trifluoromethyl)[1,1’-biphenyl]-3-yl]methoxy]benzenepropanoic Acid Hemicalcium Salt; (βS)-β-1-Propyn-1-yl-4-[[4’-(trifluoromethyl)[1,1’-biphenyl]-3-yl]methoxy]-benzenepropanoic Acid Calcium Salt (2:1)
Impurity
CAS Number 1291087-14-3
Alternate CAS # Free Acid: 865231-46-5
Molecular form C₅₂H₄₀CaF₆O₆
Appearance
Melting Point
Mol. Weight 919.94
Storage
Solubility
Stability
Category
Boiling Point
Applications AMG 837 Hemicalcium Salt is used in the synthetic preparation of a novel GPR40 receptor agonist, AMG 837 (A614410). GPR40 is a polyunsaturated fatty acid receptor that is involved with many systemic effects, which are beneficial for metabolic and inflammatory diseases. GPR40 has also been implicated as a target for treating obesity.
Dangerous Goods Info
References Walker, S.D.; et al.: Org. Process Res. Dev., 15, 570 (2011); Dragano, N. R. V., et al.: J Neuroinflammation. 14, 91 (2017); Houze, J. B., et al.: Bioorg Med Chem Lett. 22, 1267 (2012)
Extra Notes
Documents (MSDS) No Data Available
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Product Packings
10mg
50mg