Product

1-(4-Aminophenyl)cyclopentanecarbonitrile-d8

Product Name 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8
Product Code A00009854
Chemical name 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8
Synonyms
Impurity
CAS Number 115279-73-7
Alternate CAS #
Molecular form C₁₂H₆D₈N₂
Appearance
Melting Point
Mol. Weight 194.3
Storage
Solubility
Stability
Category
Boiling Point
Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
Dangerous Goods Info
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);
Extra Notes
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Product Packings
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