Product

Genistein-2',6'-d2

Product Name Genistein-2',6'-d2
Product Code DA-G070-b
Chemical name Genistein-2',6'-d2
Synonyms 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d2; Baichanin A-d2; Bonistein-d2; 4',5,7-Trihydroxyisoflavone-d2; GeniVida-d2; Genisteol-d2; NSC 36586-d2; Prunetol-d2; Sophoricol-d2; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl-3,5-d2);
Impurity NA
CAS Number 315204-48-9
Alternate CAS # NA
Molecular form C15H8D2O5
Appearance Pale Yellow Solid
Melting Point NA
Mol. Weight 272.25
Storage 2-8°C Refrigerator
Solubility NA
Stability NA
Category enzyme inhibitors,stable isotopes,tyrosine kinase inhibitors
Boiling Point NA
Applications Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.
Dangerous Goods Info NA
References NA
Extra Notes NA
Documents (MSDS) No Data Available
Keywords NA
Product Packings