Genistein-2',3',5',6'-d4 (Major)
| Product Name |
Genistein-2',3',5',6'-d4 (Major)
|
| Product Code |
DA-G070-c
|
| Chemical name |
Genistein-2',3',5',6'-d4 (Major)
|
| Synonyms |
Baichanin A-d4; Bonistein-d4; 4',5,7-Trihydroxyisoflavone-d4; GeniVida-d4; Genisteol-d4; Prunetol-d4; Sophoricol-d4; 5,7-Dihydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl-2,3,5,6-d4)-;
|
| Impurity |
NA
|
| CAS Number |
187960-08-3
|
| Alternate CAS # |
NA
|
| Molecular form |
C15H6D4O5
|
| Appearance |
Yellow Solid
|
| Melting Point |
NA
|
| Mol. Weight |
274.26
|
| Storage |
2-8°C Refrigerator
|
| Solubility |
NA
|
| Stability |
NA
|
| Category |
enzyme inhibitors,tyrosine kinase inhibitors,stable isotopes
|
| Boiling Point |
NA
|
| Applications |
Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
|
| Dangerous Goods Info |
NA
|
| References |
NA
|
| Extra Notes |
NA
|
| Documents (MSDS) |
No Data Available
|
| Keywords |
NA |
