Product

Methylnaltrexone Bromide

Product Name Methylnaltrexone Bromide
Product Code DA-N014-g
Chemical name Methylnaltrexone Bromide
Synonyms (17RS)-17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide; N-Methyl Naltrexone Bromide; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide;
Impurity NA
CAS Number 73232-52-7
Alternate CAS # NA
Molecular form C21H26BrNO4
Appearance White to Pale Brown Solid
Melting Point NA
Mol. Weight 436.35
Storage 2-8°C Hygroscopic, Refrigerator, Under Inert Atmosphere
Solubility NA
Stability NA
Category impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals
Boiling Point NA
Applications A metabolite of Naltrexone. Methylnaltrexone, a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
Dangerous Goods Info NA
References NA
Extra Notes NA
Documents (MSDS) No Data Available
Keywords NA
Product Packings