Product

Abacavir Sulfate - Impurity A (Freebase)

Product Name Abacavir Sulfate - Impurity A (Freebase)
Product Code DA-A003-10
Chemical name [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9- yl]cyclopent-2-en-1-yl]methanol
Synonyms ent-Abacavir; [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol; [(1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol; (1R,4S)-Abacavir;(1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; ((1R,4S)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol;
Impurity NA
CAS Number 136470-79-6
Alternate CAS # NA
Molecular form C14H18N6O
Appearance Off-White to Pale Yellow Solid
Melting Point NA
Mol. Weight 286.33
Storage 2-8°C Refrigerator
Solubility NA
Stability NA
Category intermediates,antiviral agents,pharmaceutical standards,enzyme inhibitors,Fine Chemicals,bases and related reagents,nucleotides
Boiling Point NA
Applications ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info NA
References NA
Extra Notes NA
Documents (MSDS) No Data Available
Keywords NA
Product Packings