Abacavir Sulfate - Impurity B (Freebase)
| Product Name |
Abacavir Sulfate - Impurity B (Freebase)
|
| Product Code |
DA-A003-09
|
| Chemical name |
6-N-Cyclopropyl-9-[(1R,4S)-4-[[(2,5-diamino-6-chloro-4- pyrimidinyl)oxy]methyl]cyclopent-2-en-1-yl]-9H-purine-2,6- diamine
|
| Synonyms |
Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine; N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; 6-(Cyclopropylamino)-9-[(1R,4S)-4-[[(2,5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine; O-Pyrimidine Derivative Abacavir; Abacavir Related Compound D (USP);
|
| Impurity |
NA
|
| CAS Number |
1443421-69-9
|
| Alternate CAS # |
NA
|
| Molecular form |
C18H21ClN10O
|
| Appearance |
NA
|
| Melting Point |
NA
|
| Mol. Weight |
428.88
|
| Storage |
2-8°C Refrigerator
|
| Solubility |
NA
|
| Stability |
NA
|
| Category |
intermediates,impurities,metabolites,pharmaceutical standards,Fine Chemicals,bases and related reagents,nucleotides
|
| Boiling Point |
NA
|
| Applications |
Abacavir EP Impurity B is a degradation product of Abacavir Sulfate. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
|
| Dangerous Goods Info |
NA
|
| References |
NA
|
| Extra Notes |
NA
|
| Documents (MSDS) |
No Data Available
|
| Keywords |
NA |
