Product

Abacavir Sulfate - Impurity D (Dihydrochloride Salt)

Product Name Abacavir Sulfate - Impurity D (Dihydrochloride Salt)
Product Code DA-A003-06
Chemical name trans-Abacavir Dihydrochloride
Synonyms (1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride; ((1R,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol Dihydrochloride;
Impurity NA
CAS Number NA
Alternate CAS # NA
Molecular form C14H20Cl2N6O
Appearance Pale Yellow to Pale Orange Solid
Melting Point NA
Mol. Weight 359.25
Storage 2-8°C Refrigerator
Solubility NA
Stability NA
Category intermediates,pharmaceutical standards,enzyme inhibitors,Fine Chemicals,bases and related reagents,nucleotides
Boiling Point NA
Applications Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info NA
References NA
Extra Notes NA
Documents (MSDS) No Data Available
Keywords NA
Product Packings