Product

Abacavir Sulfate - Impurity D (Freebase)

Product Name Abacavir Sulfate - Impurity D (Freebase)
Product Code DA-A003-03
Chemical name [(1R,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-enyl]methanol
Synonyms (1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; trans-Abacavir; {(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol (USP);
Impurity NA
CAS Number 1443421-67-7
Alternate CAS # NA
Molecular form C14H18N6O
Appearance NA
Melting Point NA
Mol. Weight 286.34
Storage 2-8°C Refrigerator
Solubility NA
Stability NA
Category Fine Chemicals,pharmaceutical standards,intermediates
Boiling Point NA
Applications (1R,​4R)​-​rel-4-​[2-Amino-​6-​(cyclopropylamino)​-​9H-​purin-​9-​yl]​-​2-​cyclopentene-​1-​methanol (Abacavir EP Impurity D) is an impurity of Abacavir). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info NA
References NA
Extra Notes NA
Documents (MSDS) No Data Available
Keywords NA
Product Packings