| Product Name |
Abacavir 5'-Phosphate
|
| Product Code |
DA-A001-46
|
| Chemical name |
Abacavir 5'-Phosphate
|
| Synonyms |
(1S,4R)- 4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Dihydrogen Phosphate (Ester);(1S-cis)-Abacavir Monophosphate; ((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl dihydrogen Phosphate;
|
| Impurity |
NA
|
| CAS Number |
136470-77-4
|
| Alternate CAS # |
NA
|
| Molecular form |
C14H19N6O4P
|
| Appearance |
White Solid
|
| Melting Point |
NA
|
| Mol. Weight |
366.31
|
| Storage |
2-8°C Refrigerator
|
| Solubility |
NA
|
| Stability |
NA
|
| Category |
phosphorylcholine derivatives,drug analogues,metabolites,pharmaceutical standards,amines,aromatics
|
| Boiling Point |
NA
|
| Applications |
Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
|
| Dangerous Goods Info |
NA
|
| References |
NA
|
| Extra Notes |
NA
|
| Documents (MSDS) |
No Data Available
|
| Keywords |
NA |
