Product

4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole

Product Name 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
Product Code DA-E093-04
Chemical name 4-[(1E,3S,5Z,8R/S,10S)-3,11-Bis-{[tert-butyl(dimethyl)silyl]oxy}-2,6,10-trimethyl-undeca-1,5-dienyl]-2-methyl-1,3-thiazole
Synonyms 4-((1E,3S,5Z,10S)-3,11-bis((tert-butyldimethylsilyl)oxy)-2,6,10-trimethylundeca-1,5-dien-1-yl)-2-methylthiazole;
Impurity NA
CAS Number 210690-85-0
Alternate CAS # NA
Molecular form C30H57NO2SSi2
Appearance Colourless Oil
Melting Point NA
Mol. Weight 552.02
Storage 2-8°C Refrigerator
Solubility NA
Stability NA
Category chiral standards,pharmaceutical standards,impurities,metabolites,fine chemicals
Boiling Point NA
Applications An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.
Dangerous Goods Info NA
References NA
Extra Notes NA
Documents (MSDS) No Data Available
Keywords NA
Product Packings